解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The human guanylate-binding protein 1 (GBP-1) is among the proteins the most highly induced by interferon-γ (IFN-γ) in every cell type investigated as yet. In vivo, GBP-1 expression is associated with the presence of inflammation and has been observed in autoimmune diseases, inflammatory bowel diseases (IBD) and cance...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs310
更新日期:2013-01-01 00:00:00
abstract::Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution (450K) DNA methylation analysis, we identified 403 differentially methylated CpG sites including known and novel potential breast cancer genes. Confirming the results in an independent validation cohort of 21 twin pairs determined th...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs321
更新日期:2013-01-01 00:00:00
abstract::Amarogentin, a secoiridoid glycoside, is an active component of the medicinal plant Swertia chirata. In this study, chemopreventive and chemotherapeutic actions of amarogentin were evaluated in a carbon tetrachloride (CCl(4))/N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis mouse model system during continuou...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs276
更新日期:2012-12-01 00:00:00
abstract::Wnt/β-Catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1-DKK4) has been shown to be important in Wnt signaling regulation. In this study, the role of DKK2, a Wnt antagonist, in epithelial ovarian cancer (EOC) was evaluated by examining ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs278
更新日期:2012-12-01 00:00:00
abstract::Our previous report demonstrated that RSK2 plays an important role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor mediated through the N-terminal kinase domain of RSK2 in JB6 Cl41 mouse skin epidermal cells in vitro. However, no direct evidence has been reported reg...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs271
更新日期:2012-12-01 00:00:00
abstract::Inflammatory tumor microenvironments play pivotal roles in the development of cancer. Inflammatory cytokines such as CXCL1/GROα exert cancer-promoting activities by increasing tumor angiogenesis. However, whether CXCL1/GROα also plays a role in the progression of prostate cancer, particularly in highly invasive castra...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs299
更新日期:2012-12-01 00:00:00
abstract::Desmosomes are intercellular junctions that confer strong cell-cell adhesion. Altered expression of desmocollin 3 (DSC3), a member of the desmosomal cadherin family, was found in various cancers; however, its functional involvement in carcinogenesis has not yet been elucidated. Expression/localization of DSC3 was anal...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs273
更新日期:2012-12-01 00:00:00
abstract::To evaluate the significance of C-C chemokine receptor type 5 (CCR5) in lung tumor development, we compared carcinogen-induced tumor growth in CCR5 knockout (CCR5(-/-)) mice and wild-type (CCR5(+/+)) mice. CCR5(-/-) mice showed reduced urethane (1g/kg)-induced tumor incidence when compared with those of CCR5(+/+) mice...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs265
更新日期:2012-12-01 00:00:00
abstract::Polymorphisms in 3' untranslated region (UTR) of cancer-related genes might affect regulation by microRNA (miRNA) and contribute to carcinogenesis. In this study, we screened several single nucleotide polymorphisms (SNPs) in 3'UTR of cancer-related genes and investigated their effects on the risk of esophageal squamou...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs259
更新日期:2012-11-01 00:00:00
abstract::Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with ...
journal_title:Carcinogenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/carcin/bgs256
更新日期:2012-11-01 00:00:00
abstract::Chondrosarcoma is a form of malignant skeletal tumor of cartilaginous origin. The non-malignant form of the disease is termed chondroma. Correctly distinguishing between the two forms is essential for making therapeutic decisions. However, due to their similar histological appearances and the lack of a reliable diagno...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs254
更新日期:2012-11-01 00:00:00
abstract::The adaptor protein regulator for ubiquitous kinase/c-Cbl-interacting protein of 85kDa (Ruk/CIN85) was found to modulate HER1/EGFR signaling and processes like cell adhesion and apoptosis. Although these features imply a role in carcinogenesis, it is so far unknown how and by which molecular mechanisms Ruk/CIN85 could...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs228
更新日期:2012-10-01 00:00:00
abstract::Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism and reduce adenoma formation in Apc(Min/+) mice. Wnt signaling is fundamental to colon carcinogenesis and is the basis for spontaneous tumorigenesis in Apc(Min/+) mice and patients wi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs174
更新日期:2012-09-01 00:00:00
abstract::Pirh2 is a Ring-H2 domain containing E3 ubiquitin ligase that targets several important tumor suppressor genes for proteasomal degradation. Overexpression of Pirh2 is frequently detected in many clinical tumor tissues including hepatocellular carcinoma (HCC). However, the molecular mechanism of Pirh2 activation in tum...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs162
更新日期:2012-08-01 00:00:00
abstract::Despite decades of research in defining the health effects of low-dose (<100 mGy) ionizing photon radiation (LDR), the relationship between LDR and human cancer risk remains elusive. Because chemical carcinogens modify the tumor microenvironment, which is critical for cancer development, we investigated the role and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs159
更新日期:2012-07-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCL...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs148
更新日期:2012-07-01 00:00:00
abstract::DNA methylation affects the aggressiveness of human malignancies. Cancers with CpG island methylator phenotype (CIMP), a distinct group with extensive DNA methylation, show characteristic features in several types of tumors. In this study, we initially defined the existence of CIMP in 41 lung adenocarcinomas (AdCas) t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs154
更新日期:2012-07-01 00:00:00
abstract::An increased neuroendocrine (NE) cell population in prostate cancer is associated with more aggressive disease and recurrence after androgen-deprivation therapy, although the mechanism responsible is unknown. In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs139
更新日期:2012-06-01 00:00:00
abstract::Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs125
更新日期:2012-05-01 00:00:00
abstract::The oncoprotein ErbB3 is overexpressed in several human cancers, for example in pancreatic adenocarcinoma and in ovarian cancers, and ErbB3-containing heterodimers have been demonstrated to be potent signaling units in carcinogenesis. This especially applies to ErbB2-ErbB3 and epidermal growth factor receptor (EGFR)-E...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs128
更新日期:2012-05-01 00:00:00
abstract::Besides polycyclic aromatic hydrocarbons (PAH) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which are established lung carcinogens, tobacco smoke also contains relatively large quantities of volatile organic carcinogens and toxicants, including 1,3-butadiene, ethylene oxide, benzene, acrolein and crotonal...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs026
更新日期:2012-04-01 00:00:00
abstract::p53 is a tumor suppressor that responds to a variety of stresses such as oncogenes and DNA damage by activating its transcriptional targets to allow repair or elimination of damaged cells. In the absence of stress signals, p53 needs to be kept in check and this is achieved by the E3 ligase MDM2. For tumors that retain...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs092
更新日期:2012-04-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via a lentiviral vector...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs020
更新日期:2012-04-01 00:00:00
abstract::Understanding the molecular pathways that contribute to the development of tamoxifen resistance is a critical research priority as acquired tamoxifen resistance is the principal cause of poor prognosis and death of patients with originally good prognosis hormone-responsive breast tumors. In this report, we provide evi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs105
更新日期:2012-04-01 00:00:00
abstract::Observational studies have been largely consistent in showing an inverse association between vitamin D and an individual's risk of developing colorectal cancer. Vitamin D protection is further supported by a range of preclinical colon cancer models, including carcinogen, genetic and dietary models. A large number of m...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgr301
更新日期:2012-03-01 00:00:00
abstract::Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr283
更新日期:2012-02-01 00:00:00
abstract::Studies have shown that fisetin, a small phytochemical molecule, has antitumor activity; however, its antiangiogenic activity has not yet been examined. Accordingly, herein, we investigated the antiangiogenic efficacy and associated mechanisms of fisetin in human umbilical vein endothelial cells (HUVECs). Fisetin (10-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr282
更新日期:2012-02-01 00:00:00
abstract::Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-caten...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr293
更新日期:2012-02-01 00:00:00
abstract::Cryptic deletions at chromosome 6q are common cytogenetic abnormalities in T-cell lymphoblastic leukemia/lymphoma (T-LBL), but the target genes have not been formally identified. Our results build on detection of specific chromosomal losses in a mouse model of γ-radiation-induced T-LBLs and provide interesting clues f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr271
更新日期:2012-02-01 00:00:00
abstract::Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive ag...
journal_title:Carcinogenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/carcin/bgr229
更新日期:2012-01-01 00:00:00
abstract::Resveratrol has elicited many provocative anticancer effects in laboratory animals and cultured cells, including reduced levels of oxidative DNA damage, inhibition of tumor initiation and progression and induction of apoptosis in tumor cells. Use of resveratrol as a cancer-preventive agent in humans will require that ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr236
更新日期:2012-01-01 00:00:00
abstract::Plumbagin (PL) (5-hydroxy-2-methyl-1,4-napthoquinone), a medicinal plant-derived naphthoquinone, was isolated from the roots of the Plumbago zeylanica L. (also known as Chitrak). The roots of P. zeylanica L. have been used in Indian medicine for >2500 years as an anti-atherogenic, cardiotonic, hepatoprotective and neu...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr249
更新日期:2012-01-01 00:00:00
abstract::Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the Western world. Inflammation may result in oxidative stress and contribute to promotion and progression of tumors, including BCC. The role of cytokines, which are inflammatory modulators, in the biology of tumors ha...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr197
更新日期:2011-12-01 00:00:00
abstract::Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids. Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vege...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr215
更新日期:2011-12-01 00:00:00
abstract::LHX4 is a member of the LIM-homeobox family and plays a critical role in pituitary development and differentiation. Several lines of evidences have reported their aberrant expression in cancers. However, the exact roles of LHX4 in carcinogenesis remain unclear. In this study, LHX4 expression was analyzed in tumor and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr219
更新日期:2011-12-01 00:00:00
abstract::Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We gen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr211
更新日期:2011-12-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNA molecules that are often located in genomic breakpoint regions and can act as oncogenes or tumor suppressor genes in human cancer. Our previous study showed that microRNA-423 (miR-423), which localized to the frequently amplified region of chromosome 17q11, was upregulated i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr199
更新日期:2011-11-01 00:00:00
abstract::Retroelements constitute a large part of the human genome. These sequences are mostly silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to their re-expression. Whether this re-expression really occurs in human cancers is largely unkown. We therefore investigated expression and DNA met...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr181
更新日期:2011-10-01 00:00:00
abstract::To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 gene...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr091
更新日期:2011-09-01 00:00:00
abstract::Cancer incidence and mortality rates show great variations across nations and between population groups. These variations are largely explained by differences in age distribution, diet and lifestyle, access to health care, cultural barriers and exposure to carcinogens and pathogens. Cancers caused by infections are si...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgr066
更新日期:2011-08-01 00:00:00